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Synthesis of Trifluoromethyl‐Substituted Cyclopropanes via Inorganic Base‐Mediated Cycloaddition Reactions
Author(s) -
Zhu Huijuan,
Liu Shuangshuang,
He Chunnian,
Zhang Jing,
Wang Lei
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900550
Subject(s) - chemistry , trifluoromethyl , cycloaddition , base (topology) , substrate (aquarium) , combinatorial chemistry , functional group , scope (computer science) , phosphate , potassium , organic chemistry , catalysis , mathematical analysis , alkyl , mathematics , polymer , computer science , oceanography , programming language , geology
An efficient and concise synthesis of various trifluoromethyl‐substituted cyclopropanes from a variety of dienes and enynes in the presence of cheap inorganic base potassium phosphate has been reported. This methodology features high yields (up to 89%), wide substrate scope and excellent functional group tolerance (25 examples).