Copper‐Catalyzed Sulfonyl Radical‐Enabled Regioselective Cyclization of 1,6‐Enynes | Zendy

Zhang JunYao | Zendy; Bao WenHui | Zendy; Qin FuHua | Zendy; Lei KeWei | Zendy; Li Qiang | Zendy; Wei WenTing | Zendy

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Copper‐Catalyzed Sulfonyl Radical‐Enabled Regioselective Cyclization of 1,6‐Enynes

Author(s) -

Zhang JunYao,

Bao WenHui,

Qin FuHua,

Lei KeWei,

Li Qiang,

Wei WenTing

Publication year - 2019

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201900539

Subject(s) - sulfonyl , chemistry , regioselectivity , intramolecular force , radical cyclization , hydrogen atom abstraction , catalysis , combinatorial chemistry , substrate (aquarium) , medicinal chemistry , radical , organic chemistry , alkyl , oceanography , geology

A copper‐catalyzed cascade cyclization of 1,6‐enynes with sulfonyl hydrazides for producing various sulfonyl‐substituted γ ‐lactams is described. This sulfonyl radical‐enabled cyclization reaction features excellent regioselectivity, mild conditions and broad substrate scope, enabling the formation of new C−S and C−C bonds through radical sulfonylation, intramolecular cyclization and hydrogen abstraction. Moreover, relevant experiments have been carried out to probe a possible mechanism.

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