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Cover Feature: Chemoselective Kumada‐Type Iron Catalysis with Alkyl Grignard Reagents: Reductive Cyclization and Cyclomethylation (Asian J. Org. Chem. 9/2019)
Author(s) -
Kim Jae Gon,
Baek Jong Hwa,
Kim Ye Ji,
Jang Yu Jeong,
Kang Eun Joo
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900507
Subject(s) - chemistry , alkyl , reagent , hydride , halide , catalysis , medicinal chemistry , electron transfer , organic chemistry , combinatorial chemistry , hydrogen
The delicate reactivities of iron(II) salts and alkyl Grignard reagents were presented in reductive cyclizations and cyclomethylation of alkyl halides having alkynes or allenes. A reduced iron complex promoted single‐electron‐transfer to afford alkyl( sp 3 )‐radical intermediates, which were cyclized to form various alkenyl( sp 2 )‐radical intermediates, which is completed by hydrogen transfer from iron hydride (Fe–H) complex or methyl coupling with Fe–Me species. The cyclomethylation reaction was found to be the effective late‐stage functionalization to provide a synergetic exploration in iron‐radical chemistry. More information can be found in the Communication by Eun Joo Kang et al. on page 1648 in Issue 9, 2019 (DOI: 10.1002/ajoc.201900359).