I 2 ‐Catalyzed Oxidative N−P Cross‐Coupling of Diarylphosphine Oxides and Sulfoximines | Zendy

Tan Mingchao | Zendy; Zheng Wenting | Zendy; Yang Lu | Zendy; Zhou Lihong | Zendy; Zeng Qingle | Zendy

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I 2 ‐Catalyzed Oxidative N−P Cross‐Coupling of Diarylphosphine Oxides and Sulfoximines

Author(s) -

Tan Mingchao,

Zheng Wenting,

Yang Lu,

Zhou Lihong,

Zeng Qingle

Publication year - 2019

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201900476

Subject(s) - chemistry , catalysis , oxidative coupling of methane , chirality (physics) , solvent , oxidative phosphorylation , coupling (piping) , coupling reaction , oxidative addition , medicinal chemistry , combinatorial chemistry , organic chemistry , metallurgy , biochemistry , chiral symmetry breaking , physics , materials science , quantum mechanics , nambu–jona lasinio model , quark

A new synthetic method for the synthesis of N‐phosphinyl sulfoximines that proceeds by an I 2 ‐catalyzed oxidative N−P cross‐coupling reaction has been developed. N‐phosphinylated sulfoximines are synthesized from sulfoximines and diarylphosphine oxides using 10 mol% I 2 as a catalyst, one equiv. H 2 O 2 as a green oxidant and PEG400 as a greener solvent. Chirality of S ‐methyl‐ S ‐phenylsulfoximine is retained in the coupling products (100% ee ).

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