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AgNO 3 ‐Catalysed Intramolecular Cyclization: Access to Functionalized Cyclopentanones and Spiro‐Cyclopentanones
Author(s) -
Bhoite Shubhangi P.,
Bansode Ajay H.,
Burate Pralhad A.,
Suryavanshi Gurunath
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900453
Subject(s) - chemistry , intramolecular force , malononitrile , aryl , substrate (aquarium) , base (topology) , combinatorial chemistry , catalysis , stereochemistry , organic chemistry , mathematical analysis , alkyl , oceanography , mathematics , geology
An efficient AgNO 3 ‐catalysed method has been developed for the synthesis of functionalized cyclopentanones and spiro‐cyclopentanones through intramolecular cyclization between ynones and cyanoacrylate/aryl/alkylidene malononitrile using DBU as a base. Easy availability of starting materials and mild reaction conditions makes this protocol more feasible over previously reported methods. The functionalized cyclopentanones and spiro‐cyclopentanones were synthesized in good to excellent yields with a broad substrate scope.