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Copper‐Catalyzed Selective Cross‐Couplings of Propargylic Ethers with Aryl Grignard Reagents
Author(s) -
Jiang Yifan,
Ma Yangyang,
Ma Enlu,
Li Zhiping
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900409
Subject(s) - chemistry , propargyl , aryl , reagent , catalysis , copper , grignard reagent , combinatorial chemistry , organic chemistry , grignard reaction , alkyl
The cross‐coupling reactions of propargylic ethers with aryl Grignard reagents were achieved by using a copper catalyst. The method presents a practical and highly selective approach for the synthesis of propargyl derivatives by using ethyl salicylate as a directing leaving group, which highlights the advantages of its easy preparation and recovery.