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Phosphine‐Catalyzed [3+2] Cycloaddition and Vinylation of Indole‐Derived α,α‐Dicyanoolefins with γ‐Substituted Allenoates
Author(s) -
Yuan Chang,
Tan Hao,
Jiang XueFei,
Liu Si,
Jiang Lu,
Cao QiYing,
Xu XingJie,
Deng XiaoYan,
Pan GuanNan,
Chen JianYang,
Cui HaiLei
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900393
Subject(s) - indole test , cycloaddition , phosphine , chemistry , catalysis , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry
A phosphine‐catalyzed [3+2] cycloaddition of γ‐substituted allenoates with α,α‐dicyanoolefins has been established, affording indole‐incorporated highly functionalized cyclopentenes. In addition, the vinylation of indole‐derived α,α‐dicyanoolefins has also been realized under the same reaction conditions by switching to indole‐derived α,α‐dicyanoolefins without protective group at N‐ 1 position.