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Enantioselective Synthesis of Alkyl Azaarenes
Author(s) -
Meazza Marta,
Rios Ramon
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900363
Subject(s) - chemistry , alkyl , enantioselective synthesis , reactivity (psychology) , nitrogen atom , organic chemistry , combinatorial chemistry , catalysis , medicine , alternative medicine , pathology
This Minireview covers reports on the enantioselective synthesis of alkyl azaarenes since 2014. It deals with the latest achievements on the reactivity of alkyl azaarenes aiming at the preparation of more complex azaarenes containing chiral centers. They rely on the activating properties of the nitrogen atom when opportunely coordinated with a metal complex or Brønsted acid and possibly containing chiral ligands. In addition, conveniently located electron‐withdrawing activating functional groups help increase the reactivity of the azaarenes. The same concepts operate in the case of vinyl azaarenes.