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Visible‐Light‐Mediated Cross‐Couplings and C−H Activation via Dual Photoredox/Transition‐Metal Catalysis in Continuous‐Flow Processes
Author(s) -
Kim Soo Dong,
Lee Jonghyun,
Kim NamJung,
Park Boyoung Y.
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900354
Subject(s) - photoredox catalysis , chemistry , catalysis , flow chemistry , transition metal , continuous flow , photochemistry , substrate (aquarium) , visible spectrum , combinatorial chemistry , reactivity (psychology) , synergistic catalysis , photocatalysis , nanotechnology , biochemical engineering , organic chemistry , optoelectronics , materials science , medicine , oceanography , alternative medicine , pathology , engineering , geology
Herein, we review dual photoredox/transition‐metal catalysis for C−C/C−N cross‐couplings and C−H activation in continuous‐flow processes. Compared to conventional transition‐metal catalysis for these reactions, visible‐light‐mediated synergistic catalysis enables the use of relatively mild and environmentally friendly reaction conditions by decreasing the activation energy and using a renewable energy source. However, photochemical transformations in batch processing have limitations such as reactivity, reaction time, substrate scope, and scalability due to light attenuation as represented by the Beer‐Lambert law. In this review article, we therefore summarize and discuss several examples of cross‐couplings and C−H activation in continuous‐flow processes that overcome these problems in batch processing.