Rapid Base‐ and Metal‐Free Oxidative C‐H Cyclization for the Synthesis of Benzo[4,5]imidazo[1,2‐ a ]pyridine Derivatives | Zendy

Lee Hae Eun | Zendy; Lee Mi Jung | Zendy; Park Jin Kyoon | Zendy

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Rapid Base‐ and Metal‐Free Oxidative C‐H Cyclization for the Synthesis of Benzo[4,5]imidazo[1,2‐ a ]pyridine Derivatives

Author(s) -

Lee Hae Eun,

Lee Mi Jung,

Park Jin Kyoon

Publication year - 2019

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201900347

Subject(s) - chemistry , pyridine , intramolecular force , base (topology) , oxidative phosphorylation , free base , metal , solvent , medicinal chemistry , chloramine t , organic chemistry , photochemistry , mathematical analysis , biochemistry , salt (chemistry) , mathematics

Metal‐free oxidative intramolecular cyclizations have been developed for the synthesis of benzo[4,5]imidazo[1,2‐ a ]pyridines. Remarkably fast reactions were observed when chloramine‐T was used as an oxidant with 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP) as the solvent, and it was noted that the reactions could be performed without using a base at room temperature.

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