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Rapid Base‐ and Metal‐Free Oxidative C‐H Cyclization for the Synthesis of Benzo[4,5]imidazo[1,2‐ a ]pyridine Derivatives
Author(s) -
Lee Hae Eun,
Lee Mi Jung,
Park Jin Kyoon
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900347
Subject(s) - chemistry , pyridine , intramolecular force , base (topology) , oxidative phosphorylation , free base , metal , solvent , medicinal chemistry , chloramine t , organic chemistry , photochemistry , mathematical analysis , biochemistry , salt (chemistry) , mathematics
Metal‐free oxidative intramolecular cyclizations have been developed for the synthesis of benzo[4,5]imidazo[1,2‐ a ]pyridines. Remarkably fast reactions were observed when chloramine‐T was used as an oxidant with 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP) as the solvent, and it was noted that the reactions could be performed without using a base at room temperature.