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Membrane Fusion through the Generation of Triazole Ceramide via Click Chemistry at the Membrane Surface
Author(s) -
Lee Seokwoo,
Lee Yun Mi,
Lee HyunJi,
Jeon Hongjun,
Lee Hyukjin,
Shin Dongyun,
Kim Sanghee
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900342
Subject(s) - chemistry , ceramide , membrane , lipid bilayer fusion , click chemistry , triazole , fusion , vesicle , liposome , biophysics , nanotechnology , combinatorial chemistry , biochemistry , organic chemistry , apoptosis , linguistics , philosophy , materials science , biology
An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu + . The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research.