Premium
Synergistic N‐Heterocyclic Carbene/Palladium‐Catalyzed Aldehyde Acylation of Allylic Amines
Author(s) -
Ohnishi Nagisa,
Yasuda Shigeo,
Nagao Kazunori,
Ohmiya Hirohisa
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900303
Subject(s) - chemistry , carbene , allylic rearrangement , catalysis , palladium , acylation , aldehyde , organic chemistry , combinatorial chemistry , medicinal chemistry
A synergistic action of a thiazolium N‐heterocyclic carbene catalyst and a palladium–bisphosphine catalyst has enabled the allylation between aldehydes acyl anions and allylic amines to afford β,γ‐unsaturated ketones, which are versatile synthetic intermediates for organic synthesis.