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Visible Light Mediated External Oxidant Free Selective C5 Bromination of 8‐Aminoquinoline Amides under Ambient Conditions
Author(s) -
Ma Bin,
Lu Fangling,
Yang Hongmei,
Gu Xin,
Li Zhen,
Li Ru,
Pei Hongqiao,
Luo Dan,
Zhang Heng,
Lei Aiwen
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900293
Subject(s) - chemistry , halogenation , catalysis , bromine , aryl , surface modification , photoredox catalysis , combinatorial chemistry , alkyl , organic chemistry , transition metal , photocatalysis
Selective functionalization of quinolines is the hot topic of organic synthesis due to its wide application in natural products, medicine, etc. In this research, C5 bromination of 8‐aminoquinoline amides have been achieved using the strategy of photoredox catalysis under mild conditions. Easily available 10‐phenylphenothiazine is employed as the organophotoredox catalyst and CBr 4 is used as the bromine source. No external oxidant or transition metal catalyst is needed in this transformation. Both the alkyl and aryl substituted carboxamides are compatible with this method.