Premium
Synthesis of Polysubstituted Pyridine Derivatives via Sequential AlCl 3 ‐Catalyzed Condensation/Aza‐Wittig/Isomerization Reactions and a Study of their Antifungal Activities
Author(s) -
Ren ZhiLin,
Su Lei,
Cai Shuang,
Lu WenTing,
Qiao Yue,
He Ping,
Ding MingWu
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900291
Subject(s) - isomerization , chemistry , wittig reaction , pyridine , catalysis , adduct , antifungal , organic chemistry , combinatorial chemistry , medicine , dermatology
A facile approach to access polysubstituted pyridine derivatives starting from Baylis‐Hillman adducts is disclosed. The reactions proceeded smoothly by sequential AlCl 3 ‐catalyzed condensation/aza‐Wittig/isomerization reactions, leading to the target products at room temperature within 24 h in moderate to good yields. Furthermore, the final products were evaluated in mycelial growth tests against Pythium dissimile , Botryotinia fuckeliana and Zymoseptoria tritici and showed potential activities.