Synthesis of Polysubstituted Pyridine Derivatives via Sequential AlCl 3 ‐Catalyzed Condensation/Aza‐Wittig/Isomerization Reactions and a Study of their Antifungal Activities | Zendy

Ren ZhiLin | Zendy; Su Lei | Zendy; Cai Shuang | Zendy; Lu WenTing | Zendy; Qiao Yue | Zendy; He Ping | Zendy; Ding MingWu | Zendy

Premium

Synthesis of Polysubstituted Pyridine Derivatives via Sequential AlCl 3 ‐Catalyzed Condensation/Aza‐Wittig/Isomerization Reactions and a Study of their Antifungal Activities

Author(s) -

Ren ZhiLin,

Su Lei,

Cai Shuang,

Lu WenTing,

Qiao Yue,

He Ping,

Ding MingWu

Publication year - 2019

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201900291

Subject(s) - isomerization , chemistry , wittig reaction , pyridine , catalysis , adduct , antifungal , organic chemistry , combinatorial chemistry , medicine , dermatology

A facile approach to access polysubstituted pyridine derivatives starting from Baylis‐Hillman adducts is disclosed. The reactions proceeded smoothly by sequential AlCl 3 ‐catalyzed condensation/aza‐Wittig/isomerization reactions, leading to the target products at room temperature within 24 h in moderate to good yields. Furthermore, the final products were evaluated in mycelial growth tests against Pythium dissimile , Botryotinia fuckeliana and Zymoseptoria tritici and showed potential activities.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research