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Efficient Carboxylation of Terminal Alkynes with Carbon Dioxide Catalyzed by Ligand‐Free Copper Catalyst under Ambient Conditions
Author(s) -
Wang WanHui,
Jia Lihong,
Feng Xiujuan,
Fang Dingqiao,
Guo Hongyu,
Bao Ming
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900288
Subject(s) - carboxylation , chemistry , catalysis , alkyne , ligand (biochemistry) , copper , carbon dioxide , solvent , ammonium , organic chemistry , combinatorial chemistry , inorganic chemistry , biochemistry , receptor
The combined use of simple copper salts and quaternary ammonium salts in a low‐boiling‐point solvent is presented as a new strategy for terminal alkyne carboxylation with CO 2 under ambient conditions. The ligand‐free copper‐catalyzed carboxylation was achieved with CuCl, n Bu 4 NOAc, and K 2 CO 3 in MeCN to produce various propiolic acids in high to excellent yields.