Efficient Carboxylation of Terminal Alkynes with Carbon Dioxide Catalyzed by Ligand‐Free Copper Catalyst under Ambient Conditions | Zendy

Wang WanHui | Zendy; Jia Lihong | Zendy; Feng Xiujuan | Zendy; Fang Dingqiao | Zendy; Guo Hongyu | Zendy; Bao Ming | Zendy

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Efficient Carboxylation of Terminal Alkynes with Carbon Dioxide Catalyzed by Ligand‐Free Copper Catalyst under Ambient Conditions

Author(s) -

Wang WanHui,

Jia Lihong,

Feng Xiujuan,

Fang Dingqiao,

Guo Hongyu,

Bao Ming

Publication year - 2019

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201900288

Subject(s) - carboxylation , chemistry , catalysis , alkyne , ligand (biochemistry) , copper , carbon dioxide , solvent , ammonium , organic chemistry , combinatorial chemistry , inorganic chemistry , biochemistry , receptor

The combined use of simple copper salts and quaternary ammonium salts in a low‐boiling‐point solvent is presented as a new strategy for terminal alkyne carboxylation with CO 2 under ambient conditions. The ligand‐free copper‐catalyzed carboxylation was achieved with CuCl, n Bu 4 NOAc, and K 2 CO 3 in MeCN to produce various propiolic acids in high to excellent yields.

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