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Brønsted Acid‐Catalyzed Cyclization of β ‐Amino‐1,4‐enols to Oxazol‐2(3 H )‐ones and 5‐Alkenyloxazolidin‐2‐ones
Author(s) -
Zhao Yichao,
Henry Stuart Adam,
Jin Jianwen,
Clarkson Guy James,
Chan Philip Wai Hong
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900277
Subject(s) - chemistry , brønsted–lowry acid–base theory , catalysis , ethanol , medicinal chemistry , enol , organic chemistry , stereochemistry , combinatorial chemistry
A synthetic method to prepare oxazol‐2(3 H )‐ones and 5‐alkenyloxazolidin‐2‐ones efficiently that relies on a Brønsted acid‐catalyzed cyclization of the respective secondary and tertiary β ‐amino‐1,4‐enols in ethanol is described. The reaction did not require the exclusion of air or moisture.