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Synthesis of Pyrimidines with Ammonium Acetate as Nitrogen Source Under Solvent‐Free Conditions
Author(s) -
Wang Peigen,
Zhang Xueguo,
Liu Yafeng,
Chen Baohua
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900248
Subject(s) - chemistry , ammonium acetate , chalcone , nitrogen , solvent , ammonium , tandem , ring (chemistry) , alcohol , organic chemistry , benzyl alcohol , catalysis , materials science , high performance liquid chromatography , composite material
Abstract A three‐component tandem reaction for the synthesis of multisubstituted pyrimidines from chalcone, benzyl alcohol and NH 4 OAc have been developed. This transformation represents an example for the simultaneous formation of two new C(sp 2 )−N bonds and a six‐membered ring using NH 4 OAc as nitrogen source under solvent‐free conditions.