Premium
Cover Feature: Catalytic Desymmetrization of 1,3‐Difluoropropan‐2‐ols via C−F Bond Activation Using a Phosphazene Base Affords Monofluoromethyl‐Substituted Epoxides (Asian J. Org. Chem. 5/2019)
Author(s) -
Wang Jiandong,
Tanaka Junki,
Tokunaga Etsuko,
Shibata Norio
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900245
Subject(s) - chemistry , phosphazene , catalysis , fluorine , halogen bond , cover (algebra) , desymmetrization , bond dissociation energy , polymer chemistry , silylene , dissociation (chemistry) , halogen , photochemistry , stereochemistry , medicinal chemistry , organic chemistry , silicon , polymer , mechanical engineering , alkyl , engineering , enantioselective synthesis
C−F bonds are usually inert and stable , but when using certain catalysts, the C−F bond can be easily transformed into a C−O bond, despite the bond‐dissociation energy barrier. In fact, fluorine is a much better communicator than other halogens such as chlorine, when assisted by silicon and an organic base. More information can be found in the Communication by Norio Shibata et al. on page 641 in Issue 5, 2019 (DOI: 10.1002/ajoc.201900157). Graphic credit: Mami Shibata, a painter of Japanese art; the title of her work is “Koeno no Katachi” (Communications).