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Potassium‐Persulfate‐Promoted Regioselective Azidation/Cyclization of 1,6‐Enynes
Author(s) -
Wang YiNing,
Li Qiang,
Fang YiLin,
Gao LeHan,
Song SiZhe,
Dong Youren,
Wei WenTing
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900210
Subject(s) - regioselectivity , chemistry , potassium persulfate , persulfate , amine gas treating , combinatorial chemistry , catalysis , organic chemistry , polymerization , polymer
An efficient, environmentally benign and sustainable method for the synthesis of 2‐pyrrolidinones from 1,6‐enynes via an unusual regioselective azidation/cyclization is described. The products have been obtained in good yields without the assistance of any transition‐metal catalysts or ligands. To demonstrate the utility of this protocol, the azidation products are converted to a synthetically valuable amine or triazole. This azidation cyclization involves a radical process, allows a regioselective way toward the formation of one C−N bond and one C−C bond.