Metal‐Free Regioselective Carbonylation of Imidazo[1,2‐ a ]pyridines via Photoredox Catalysis using Nitrones | Zendy

Tang Fang | Zendy; Guan Zhi | Zendy; He YanHong | Zendy

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Metal‐Free Regioselective Carbonylation of Imidazo[1,2‐ a ]pyridines via Photoredox Catalysis using Nitrones

Author(s) -

Tang Fang,

Guan Zhi,

He YanHong

Publication year - 2019

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201900202

Subject(s) - chemistry , carbonylation , regioselectivity , catalysis , pyridine , photoredox catalysis , combinatorial chemistry , photosensitizer , photochemistry , organic chemistry , photocatalysis , carbon monoxide

Imidazo[1,2‐ a ]pyridine is an important skeletal structure of many drug molecules. A novel metal‐free regioselective C3 carbonylation of imidazo[1,2‐ a ]pyridines via visible light photoredox catalysis using nitrones is described. 9‐Mesityl‐10‐methylacridinium ion (Acr + −Mes) acts as an efficient organic photosensitizer and molecular oxygen acts as an oxidant. This work provides a greener and convenient alternative to the C3 carbonylation of imidazo[1,2‐ a ]pyridines. Mild reaction conditions and a wide range of substrates make this method of great potential application value in medicinal chemistry and organic synthesis.

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