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Copper‐Mediated Direct and Selective C−H Thiolation of Quinazolinones
Author(s) -
Sarkar Writhabrata,
Mishra Aniket,
Bhowmik Arup,
Deb Indubhusan
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900199
Subject(s) - chemistry , reagent , moiety , combinatorial chemistry , copper , bond cleavage , pyridine , pyrimidine , stereochemistry , organic chemistry , catalysis
Direct thiolation of quinazolinones by selective cleavage of a relatively inert C−H bond, mediated by earth‐abundant copper and guided by a pyridine or pyrimidine moiety, has been achieved under operationally simple conditions. The devised protocol does not require any toxic or reactive reagents and provides direct access to a broad spectrum of pharmaceutically relevant thioquinazolinones.