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Front Cover: Stereoselective Synthesis of the Spirocyclic Ring System of the Sesquiterpene Spirolepechinene (Asian J. Org. Chem. 4/2019)
Author(s) -
Duhamel Nina,
Larcher Roberto,
Guella Graziano,
Pilkington Lisa I.,
Fedrizzi Bruno,
Barker David
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900191
Subject(s) - chemistry , front cover , sesquiterpene , stereochemistry , stereoselectivity , natural product , total synthesis , ring (chemistry) , cover (algebra) , organic chemistry , catalysis , mechanical engineering , engineering
Spirolepechinene , reported to be found in a number of natural plant sources including grapevine (Vitis vinifera), is a member of the rare spirojatamane class of sesquiterpenes with a unique relative stereochemistry about its spirocentre. Owing to its unique structural scaffold, spirolepechinene is an extremely desirable synthetic target. An efficient method for the generation of the core spirocyclic motif of spirolepechinene from acetylcyclohexanone has been developed, allowing for confirmation of the relative stereochemistry of this natural product. More information can be found in the Communication by David Barker et al. on page 462 in Issue 4, 2019 (DOI: 10.1002/ajoc.201900151).