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Synthesis of 1 H ‐Inden‐1‐ylidenes via Carboannulation of Internal Alkynes with ( E )‐3‐(2‐Bromophenyl) Acrylaldehyde: Potential Precursors for Drug Development
Author(s) -
Dhanorkar Ritesh J.,
Gupta Virendra Kumar,
Prakash Gocher Chandra
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900183
Subject(s) - chemistry , indene , annulation , alkyne , combinatorial chemistry , palladium , oxidative phosphorylation , catalysis , medicinal chemistry , stereochemistry , organic chemistry , biochemistry
Abstract 1 H ‐Inden‐1‐ylidene derivatives have been synthesized using a simple and efficient Pd‐catalyzed annulation of functionalized (E)‐3‐(2‐bromophenyl) acrylaldehyde with internal alkynes. The proposed mechanism involves an oxidative addition and carbopalladation of an alkyne to generate a vinyl palladium intermediate followed by β ‐hydrogen elimination. These pre‐functionalized indene‐based cyclic precursors can be potential bioactive systems for drug discovery and development.