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Peroxydisulfate‐Mediated Transition‐Metal‐Free Oxidative C(sp 3 )−H Bond Lactonization
Author(s) -
NozawaKumada Kanako,
Kurosu Satoshi,
Shigeno Masanori,
Kondo Yoshinori
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900167
Subject(s) - chemistry , peroxydisulfate , halogen , transition metal , nitro , medicinal chemistry , primary (astronomy) , oxidative phosphorylation , organic chemistry , catalysis , biochemistry , alkyl , physics , astronomy
An inexpensive, powerful, and eco‐friendly method for transition‐metal‐free oxidative C(sp 3 )−H bond lactonization was developed using sodium peroxydisulfate as the sole oxidant. The cyclization of 2‐alkylbenzoic acids containing a primary, secondary or tertiary carbon at the benzylic position proceeded smoothly, affording a variety of lactone derivatives. Furthermore, various functional groups such as halogen, cyano, nitro and hydroxy groups were tolerated under the reaction conditions.