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Catalytic Enantioselective Aldol‐Type Reaction Using α‐Fluorinated Enolates
Author(s) -
Gong Yi,
Yu JinSheng,
Hao YongJia,
Zhou Ying,
Zhou Jian
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900071
Subject(s) - enantioselective synthesis , aldol reaction , chemistry , catalysis , optically active , organic chemistry , combinatorial chemistry , organocatalysis , fluorine
Optically active α‐fluoroalkyl substituted alcohols are widely present in drugs and pharmaceutically active compounds. Catalytic enantioselective aldol‐type reaction using fluorinated enolates constitutes a powerful method for the synthesis of α‐fluorinated β‐hydroxy carbonyl compounds, which are versatile building blocks to access α‐fluorinated alcohols bearing different functionalities through an array of transformations based on carbonyl group. This Focus Review summarizes recent achievements of the catalytic enantioselective aldol reactions using fluorinated enolates derived from five different types of precursors, discusses in detail the limitation of each method, and outlines synthetic opportunities still present.