Direct C2‐Heteroarylation of Indoles by Rhodium‐Catalyzed C−C Bond Cleavage of Secondary Alcohols | Zendy

Yu TianYang | Zendy; Zheng ZhaoJing | Zendy; Sun Wei | Zendy; Qiao ZiHeng | Zendy

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Direct C2‐Heteroarylation of Indoles by Rhodium‐Catalyzed C−C Bond Cleavage of Secondary Alcohols

Author(s) -

Yu TianYang,

Zheng ZhaoJing,

Sun Wei,

Qiao ZiHeng

Publication year - 2019

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201900069

Subject(s) - chemistry , rhodium , catalysis , bond cleavage , reactivity (psychology) , cleavage (geology) , inert , medicinal chemistry , organic chemistry , combinatorial chemistry , medicine , alternative medicine , geotechnical engineering , pathology , fracture (geology) , engineering

A rhodium‐catalyzed direct heteroarylation of indoles by cleavage of an inert C−C bond of alcohols is reported. This catalytic system exhibits high reactivity and tolerates various functional groups. This reaction provides a tool for the rapid construction of biheteroaryls without pre‐activation of the starting materials. Control experiments were conducted to determine a possible mechanism. This reaction makes a significant contribution to the field of C−C bond activation of alcohols.

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