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Direct C2‐Heteroarylation of Indoles by Rhodium‐Catalyzed C−C Bond Cleavage of Secondary Alcohols
Author(s) -
Yu TianYang,
Zheng ZhaoJing,
Sun Wei,
Qiao ZiHeng
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900069
Subject(s) - chemistry , rhodium , catalysis , bond cleavage , reactivity (psychology) , cleavage (geology) , inert , medicinal chemistry , organic chemistry , combinatorial chemistry , medicine , alternative medicine , geotechnical engineering , pathology , fracture (geology) , engineering
A rhodium‐catalyzed direct heteroarylation of indoles by cleavage of an inert C−C bond of alcohols is reported. This catalytic system exhibits high reactivity and tolerates various functional groups. This reaction provides a tool for the rapid construction of biheteroaryls without pre‐activation of the starting materials. Control experiments were conducted to determine a possible mechanism. This reaction makes a significant contribution to the field of C−C bond activation of alcohols.