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Sulfide‐Catalyzed Trifluoromethylthiolation‐Cyclization of Tryptamine Derivatives
Author(s) -
Guo Rui,
Cai Baohua,
Jin Ming Yu,
Mu Huaixue,
Wang Jun Joelle
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900068
Subject(s) - chemistry , tryptamine , sulfide , catalysis , cascade , organic chemistry , combinatorial chemistry , biochemistry , chromatography
A catalytic method for the incorporation of an SCF 3 group to tryptamine derivatives was developed via a sulfide‐catalyzed cascade trifluoromethylthiolation‐cyclization. A series of C(3)‐CF 3 S pyrrolidinoindolines were obtained in moderate to good yields under mild conditions. Furthermore, some enantioselectivity was observed when using chiral sulfide thiocineole as a catalyst.