Front Cover: Selective Introduction of Trifluoroacetyl Group to β‐ and δ‐Position of Aromatic Conjugated Esters: Facile Synthesis of Fluorine‐containing Keto Esters (Asian J. Org. Chem. 3/2019)

The synthesis of partially fluorinated organic compounds is one of the most attractive topics in synthetic organic chemistry, and especially in medicinal chemistry, in recent years. A regioselective and direct introduction of a trifluoroacetyl group into electron‐deficient carbon atoms of aromatic conjugated esters is described herein. The reaction proceeds in good yields through a magnesium‐promoted reduction in the presence of ethyl trifluoroacetate as a fluorine‐containing carbon source. More information can be found in the Communication by Hirofumi Maekawa et al. on page 344 in Issue 3, 2019 (DOI: 10.1002/ajoc.201800741).