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Front Cover: Selective Introduction of Trifluoroacetyl Group to β‐ and δ‐Position of Aromatic Conjugated Esters: Facile Synthesis of Fluorine‐containing Keto Esters (Asian J. Org. Chem. 3/2019)
Author(s) -
Zhang Tianyuan,
Shimizu Yuhei,
Shimizu Kazuyuki,
Abe Mitsuhiro,
Zheng Suhua,
Maekawa Hirofumi
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900060
Subject(s) - chemistry , conjugated system , regioselectivity , fluorine , front cover , organic chemistry , carbon fibers , organic synthesis , group (periodic table) , cover (algebra) , catalysis , polymer , mechanical engineering , engineering , materials science , composite number , composite material
The synthesis of partially fluorinated organic compounds is one of the most attractive topics in synthetic organic chemistry, and especially in medicinal chemistry, in recent years. A regioselective and direct introduction of a trifluoroacetyl group into electron‐deficient carbon atoms of aromatic conjugated esters is described herein. The reaction proceeds in good yields through a magnesium‐promoted reduction in the presence of ethyl trifluoroacetate as a fluorine‐containing carbon source. More information can be found in the Communication by Hirofumi Maekawa et al. on page 344 in Issue 3, 2019 (DOI: 10.1002/ajoc.201800741).