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Auto‐Oxidation‐Induced Construction of Isatins from Glycine Derivatives
Author(s) -
Min Wenjian,
Li Haitao,
Quan Zhengjun,
Yang Caixia,
Huo Congde
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900043
Subject(s) - chemistry , glycine , combinatorial chemistry , organic chemistry , amino acid , biochemistry
An oxygenation approach to isatins via an auto‐oxidation/intramolecular annulation tandem reaction of glycine derivatives is described. This transformation provides a metal‐free protocol for the preparation of isatin derivatives, which are important structural motifs widely found in organic molecules with various functions and privileged units for the synthesis of complex heterocycles. The reaction proceeds smoothly under mild reaction conditions and requires only Brønsted acid and oxygen.