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Metal‐Free Regioselective Oxynitration of Acrylamides: Synthesis of 1,2‐Nitro Alcohols
Author(s) -
Gao LeHan,
Meng XiaoXiao,
Wang YiNing,
Song SiZhe,
Ge GuoPing,
Dong Youren,
Wei WenTing,
Liu YanYun,
Li Qiang
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900019
Subject(s) - regioselectivity , chemistry , nitro , nitrite , metal , combinatorial chemistry , organic chemistry , catalysis , nitrate , alkyl
A metal‐free oxynitration of acrylamides with commercially available tert ‐butyl nitrite and easily available air was achieved through a regioselective pathway. A wide range of 1,2‐nitro alcohols were thus eciently synthesized in a novel route under mild conditions. The reaction involves a radical process, allows a highly regioselective strategy toward the formation of new C−N and C−O bonds in one step.