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Asymmetric 1,3‐Dipolar Cycloaddition Reactions of Enones by Primary Amine Catalysis
Author(s) -
Yang Qi,
Zhang Jieyu,
Jia Zongbin,
Yang Chunming,
Zhang Long,
Luo Sanzhong
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900013
Subject(s) - stereocenter , chemistry , cycloaddition , amine gas treating , primary (astronomy) , catalysis , bicyclic molecule , 1,3 dipolar cycloaddition , combinatorial chemistry , organocatalysis , organic chemistry , enantioselective synthesis , physics , astronomy
We report herein a 1,3‐dipolar cycloaddition between enones and nitrones with good to excellent distereo‐ and enantioselectivities by a chiral primary amine catalyst, which furnishes an operationally simple synthetic protocol for the fused bicyclic isoxazolidine derivatives with multiple stereogenic centers.