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Isocyanide‐Based Multicomponent Reactions: A Concise Approach to 2‐Amino‐3‐perfluoroalkylfurans Using Methyl Perfluoroalk‐2‐ynoates as Fluorinated Building Blocks
Author(s) -
Wang Yedong,
Tao Lili,
Chen Jie,
He Weimin,
Deng Hongmei,
Shao Min,
Zhang Hui,
Cao Weiguo
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201900010
Subject(s) - chemistry , isocyanide , organic chemistry , combinatorial chemistry , computational chemistry
Synthesis of 2‐amino‐3‐perfluoroalkylfurans has been accomplished by isocyanide‐based multicomponent reactions. Using methyl perfluoroalk‐2‐ynoates as the fluorinated build blocks in combination with isocyanides and aromatic aldehydes in one‐pot at room temperature, the perfluoroalkyl‐substituted 2‐aminofurans were obtained in good to excellent yields.