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Visible‐Light‐Induced, Manganese‐Catalyzed Tandem Cyclization of 2‐Biphenyl Isocyanides with Cyclopropanols for the Synthesis of 6‐ β ‐Ketoalkyl Phenanthridines
Author(s) -
Wang Liping,
Ding Qiuping,
Li Xiaofang,
Peng Yiyuan
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800733
Subject(s) - chemistry , biphenyl , manganese , catalysis , tandem , alkyl , transformation (genetics) , combinatorial chemistry , medicinal chemistry , photochemistry , organic chemistry , biochemistry , materials science , composite material , gene
A visible‐light‐induced, manganese‐catalyzed protocol for the synthesis of 6‐ β ‐keto alkyl phenanthridines has been developed efficiently from 2‐biphenyl isocyanides and cyclopropanols in the absence of an external oxidant. This transformation is amenable to various isocyanides and tertiary cyclopropanols under catalytic amounts of Mn(acac) 3 (10 mol%).