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Palladium‐Catalyzed C( sp 2 )−H Activation for the Formation of C−N Bonds: Rapid Access to Benzimidazoquinazolines
Author(s) -
Guo Xiaolong,
Hu Jing,
Zhang Mengmeng,
Wang Luyao
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800710
Subject(s) - chemistry , catalysis , palladium , combinatorial chemistry , azole , medicinal chemistry , stereochemistry , organic chemistry , antifungal , medicine , dermatology
A convenient and effective method for Pd‐catalyzed cross‐dehydrogenative C( sp 2 )−H/N−H couplings to synthesize fused N‐heterocyclic benzimidazoquinazoline derivatives was developed. The reaction employs Pd(OAc) 2 as the catalyst and Cu(OAc) 2 or O 2 (from the air) as the terminal oxidant. The strategy uses simple and easily accessible substrates. This method provides a route to azole‐fused heterocycles.