Premium
Tin‐Mediated One‐Pot Preparation of β‐Trifluoromethyl‐β ‐ acylhydrazonyl Carbonyl Compounds
Author(s) -
Wang KeHu,
Shi Baobao,
Wang Yalin,
Wang Jianglong,
Huang Danfeng,
Su Yingpeng,
Hu Yulai
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800693
Subject(s) - chemistry , hemiacetal , trifluoromethyl , tin , organic chemistry , combinatorial chemistry , alkyl
A concise and efficient protocol for the preparation of β‐trifluoromethyl‐β‐acylhydrazonyl carbonyl compounds was developed from multicomponent one‐pot reactions of trifluoroacetaldehyde methyl hemiacetal, acylhydrazines and 2‐bromocarbonyl compounds in the presence of tin powder. The reactions can be carried out under mild reaction conditions to give the products in good to excellent yields.