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Highly Efficient Construction of Pentacyclic Carboline‐Containing Salts via a [Cp*RhCl 2 ] 2 ‐Catalyzed Tandem Reaction
Author(s) -
Wang Zhuo,
Li Tongyu,
Xing Siyang,
Zhu Bolin
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800642
Subject(s) - chemistry , tandem , catalysis , double bond , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , composite material , materials science
A [Cp*RhCl 2 ] 2 ‐catalyzed tandem reaction of indolyl aldehydes, amines, and alkynes featuring the formation of two C−C bonds, two C−N bonds, and one C=N bond is described. This strategy involves double C−H activation and double insertion of alkynes, furnishing a series of pentacyclic carboline‐containing salts in good yields under mild conditions. It provides a good choice for rapidly constructing libraries of such pentacyclic carboline‐containing salts.
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