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Asymmetric Brook Rearrangement
Author(s) -
Lee Nicholas,
Tan ChoonHong,
Leow Dasheng
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800585
Subject(s) - enantioselective synthesis , chemistry , cope rearrangement , stereochemistry , organic chemistry , catalysis
Although the Brook rearrangement has been discovered over fifty years ago, there remains significant opportunities for chemists to make new discoveries relating to this reaction. Majority of the examples in the literature report Brook rearrangements using racemic starting materials. In this Focus Review, we highlight asymmetric variants of Brook rearrangements, focusing on enantioselective and enantiospecific examples.