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DMSO‐Promoted Metal‐Free Aerobic Oxidation of Heterobenzylic Methylene to Prepare N‐Heterocyclic Ketones
Author(s) -
Zhang Yanyan,
Yue Yuanyuan,
Wang Xiaopei,
Wang Ke,
Lou Yixiao,
Yao Meihuan,
Zhuo Kelei,
Lv Qingzhang,
Liu Jianming
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800576
Subject(s) - chemistry , methylene , oxygenation , reaction conditions , metal , combinatorial chemistry , molecular oxygen , organic chemistry , medicinal chemistry , oxygen , catalysis , ecology , biology
Using O 2 as the terminal oxidant, the direct oxygenation of heterobenzylic C−H bonds can be achieved in DMSO. Various N ‐heteroaryl ketones were provided with good yields through the protocol. It can also be conducted on a gram scale with good reaction efficiency. DMSO plays an important role in this selective oxygenation reaction of heterobenzylic methylenes.