DMSO‐Promoted Metal‐Free Aerobic Oxidation of Heterobenzylic Methylene to Prepare N‐Heterocyclic Ketones | Zendy

Zhang Yanyan | Zendy; Yue Yuanyuan | Zendy; Wang Xiaopei | Zendy; Wang Ke | Zendy; Lou Yixiao | Zendy; Yao Meihuan | Zendy; Zhuo Kelei | Zendy; Lv Qingzhang | Zendy; Liu Jianming | Zendy

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DMSO‐Promoted Metal‐Free Aerobic Oxidation of Heterobenzylic Methylene to Prepare N‐Heterocyclic Ketones

Author(s) -

Zhang Yanyan,

Yue Yuanyuan,

Wang Xiaopei,

Wang Ke,

Lou Yixiao,

Yao Meihuan,

Zhuo Kelei,

Lv Qingzhang,

Liu Jianming

Publication year - 2018

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201800576

Subject(s) - chemistry , methylene , oxygenation , reaction conditions , metal , combinatorial chemistry , molecular oxygen , organic chemistry , medicinal chemistry , oxygen , catalysis , ecology , biology

Using O 2 as the terminal oxidant, the direct oxygenation of heterobenzylic C−H bonds can be achieved in DMSO. Various N ‐heteroaryl ketones were provided with good yields through the protocol. It can also be conducted on a gram scale with good reaction efficiency. DMSO plays an important role in this selective oxygenation reaction of heterobenzylic methylenes.

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