Pd/Zn Co‐catalyzed Asymmetric Ring‐Opening Reactions of Aza/Oxabicyclic Alkenes with Oximes | Zendy

Shen Guoli | Zendy; Khan Ruhima | Zendy; Yang Fan | Zendy; Yang Yong | Zendy; Pu Dongdong | Zendy; Gao Yang | Zendy; Zhan Yong | Zendy; Luo Yang | Zendy; Fan Baomin | Zendy

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Pd/Zn Co‐catalyzed Asymmetric Ring‐Opening Reactions of Aza/Oxabicyclic Alkenes with Oximes

Author(s) -

Shen Guoli,

Khan Ruhima,

Yang Fan,

Yang Yong,

Pu Dongdong,

Gao Yang,

Zhan Yong,

Luo Yang,

Fan Baomin

Publication year - 2019

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201800569

Subject(s) - chemistry , nucleophile , catalysis , substrate (aquarium) , ring (chemistry) , enantioselective synthesis , ligand (biochemistry) , medicinal chemistry , reaction conditions , combinatorial chemistry , organic chemistry , stereochemistry , biochemistry , oceanography , receptor , geology

An application of various oximes as nucleophiles in the asymmetric ring‐opening (ARO) reaction of aza/oxabicyclic alkenes resulting in cis ‐ARO products has been developed. The reaction was co‐catalyzed by Pd(OAc) 2 and Zn(OTf) 2 with ( R )‐DIFLUORPHOS as the chiral ligand. This methodology exhibits broad substrate scope, functional group tolerance with high enantioselectivity. A synthetic application of this method has been demonstrated.

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