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Cobalt‐Catalyzed Reductive Coupling of Alkynes and Acrylates Bearing a Leaving Group: Construction of Cyclobutene Rings
Author(s) -
Fujihara Tetsuaki,
Kukita Susumu,
Yagi Yuki,
Kirihara Maho,
Nogi Keisuke,
Tsuji Yasushi
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800561
Subject(s) - cyclobutene , chemistry , catalysis , cobalt , lewis acids and bases , acetonitrile , medicinal chemistry , group (periodic table) , bearing (navigation) , polymer chemistry , photochemistry , organic chemistry , ring (chemistry) , cartography , geography
This study reports a cobalt‐catalyzed synthesis of cyclobutenes using alkynes and acrylates bearing a leaving group at the α position. The cyclobutene formation was facilitated by an appropriate proton source. In the presence of a Lewis acid, acetonitrile participated in the reaction, affording the corresponding functionalized cyclobutenes.