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Chiral Bifunctional Ferrocenylphosphine‐Catalyzed Enantioselective Allylic Alkylation of Morita−Baylis−Hillman Carbonates with Pyrazolin‐5‐ones
Author(s) -
Luo Wenjun,
Song Dingguo,
Fang Lu,
Nian Sanfei,
Hou Huacui,
Ling Fei,
Zhong Weihui
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800547
Subject(s) - chemistry , bifunctional , enantioselective synthesis , tsuji–trost reaction , allylic rearrangement , catalysis , alkylation , organic chemistry
A chiral bifunctional ferrocenylphosphine catalyzed asymmetric allylic alkylation of Morita−Baylis−Hillman (MBH) carbonates with pyrazolin‐5‐ones was developed. The reaction afforded the desired pyrazolone derivatives in moderate to good yields (up to 80%), and with high enantioselectivities (up to 98% ee ).