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Palladium‐Catalyzed Cross‐Coupling of Arylboronic Acid and Benzonitriles Using DMSO as the Methylene Source
Author(s) -
Ai HanJun,
Qi Xinxin,
Peng JinBao,
Ying Jun,
Wu XiaoFeng
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800502
Subject(s) - chemistry , palladium , phenylboronic acid , methylene , catalysis , yield (engineering) , coupling (piping) , organic chemistry , combinatorial chemistry , medicinal chemistry , materials science , metallurgy , mechanical engineering , engineering
An interesting strategy on palladium‐catalyzed cross‐coupling of arylboronic acids and benzonitriles has been developed. In this approach, DMSO was utilized as the methylene source and reacted with benzamides (generated in situ from benzonitriles) to form an N ‐acyliminium cation, followed by palladium‐catalyzed cross‐coupling with phenylboronic acids to afford the final products. A variety of the desired products were obtained in moderate to excellent yield.