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Copper‐Mediated Synthesis of (Diethylphosphono)difluoromethyl Thioethers from Diazonium Salts, NaSCN, and TMS‐CF 2 PO(OEt) 2
Author(s) -
Ou Yang,
Gooßen Lukas J.
Publication year - 2019
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800461
Subject(s) - chemistry , thiocyanate , copper , medicinal chemistry , potassium thiocyanate , fluorine , organic chemistry
An expedient one‐pot synthesis of (diethylphosphono) difluoromethyl thioethers is described consisting of a Sandmeyer thiocyanation with in situ‐fluoroalkylation using TMS‐CF 2 PO(OEt) 2 as the fluorine source. Both steps are mediated by copper(I) thiocyanate. The reaction is applicable to a wide range of functional groups, as demonstrated by 22 examples.
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