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Synthesis and Cytotoxicity of (±)‐9‐Hydroxy‐5‐oxo‐2,3,4,5‐tetrahydro‐1 H ‐benzo[ b ]azepine‐2‐carboxamide: An Active Component of Juglans regia
Author(s) -
Marepu Nagaraju,
Yeturu Sunandamma,
Pal Manojit
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800425
Subject(s) - chemistry , azepine , stereochemistry , heck reaction , juglans , natural product , benzazepine , cytotoxicity , palladium , organic chemistry , in vitro , catalysis , biochemistry
A total synthesis of a benzazepine natural product[1][Li. Qian, 2017] was achieved via an alternative strategy using a Strecker‐type synthesis/Heck coupling process to construct the core ring. A comparison of spectral data of the target molecule with the previously reported one suggested the need for structure revision. The compound described herein also showed cytotoxic properties.