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Palladium/Copper Co‐Catalyzed Cascade Metallo‐ene/Sonogashira Coupling Reaction of Allenamides
Author(s) -
Liang Hanbing,
Meng Long,
Chi Xiaochen,
Yao Shuzhi,
Chen Hongshuai,
Jiao Luyang,
Liu Qing,
Zhang Daopeng,
Liu Hui,
Dong Yunhui
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800377
Subject(s) - sonogashira coupling , chemistry , palladium , catalysis , copper , medicinal chemistry , ene reaction , coupling reaction , triple bond , combinatorial chemistry , organic chemistry , stereochemistry , double bond
A mild and efficient type of Pd/Cu‐catalyzed allenamide allyl acetate reaction with terminal alkynes affording polyfunctionalized 2,3‐dihydropyrrole derivatives is reported. Allenamide substrates went through two π‐allyl palladium complex processes, and then it was trapped by terminal alkynes on the distal position via a Sonogashira reaction. Two new C sp 3 − C sp 2 and C sp 3 − C sp bonds were efficiently constructed in one pot.