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Copper‐Catalyzed N‐Arylation with Boronic Acid Pinacol Esters
Author(s) -
Liu Shuai,
Xu Liang
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800371
Subject(s) - chemistry , pinacol , boronic acid , catalysis , copper , chelation , aryl , organic chemistry , combinatorial chemistry , alkyl
A copper‐catalyzed facile N‐arylation of 2‐acyl substituted anilines has been disclosed. Through chelation assistance of the weakly coordinating carbonyl groups, the Chan−Evans−Lam (CEL) C−N cross‐coupling reactions proceeded at room temperature in open flasks. Furthermore, such chelation effects also enabled the direct utilization of aryl boronic acid pinacol esters in Cu‐catalyzed CEL reactions under mild conditions.