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Iron‐Catalyzed Aerobic Oxidative Cleavage and Construction of C−N Bonds: A Facile Method for Synthesis of 2,4,6‐Trisubstituted Pyridines
Author(s) -
Gopalaiah Kovuru,
Rao Devarapalli Chenna,
Mahiya Kuldeep,
Tiwari Ankit
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800312
Subject(s) - chemistry , catalysis , oxidative cleavage , tandem , pyridine , oxidative phosphorylation , combinatorial chemistry , molecular oxygen , bond cleavage , reaction conditions , organic chemistry , biochemistry , materials science , composite material
Abundant and inexpensive iron, readily catalyzed the oxidative tandem reactions of arylalkylketones and benzylamines using molecular oxygen as the green oxidant in one‐pot solvent‐free conditions. 2,4,6‐Triaryl pyridines containing a wide variety of functional groups are synthesized from easily available starting materials. The synthetic importance of this reaction protocol has been demonstrated by preparing topoisomerase I and II inhibitors, and other valuable pyridine derivatives. Key intermediates are isolated and a plausible mechanism has been proposed.