Iron‐Catalyzed Aerobic Oxidative Cleavage and Construction of C−N Bonds: A Facile Method for Synthesis of 2,4,6‐Trisubstituted Pyridines | Zendy

Gopalaiah Kovuru | Zendy; Rao Devarapalli Chenna | Zendy; Mahiya Kuldeep | Zendy; Tiwari Ankit | Zendy

Premium

Iron‐Catalyzed Aerobic Oxidative Cleavage and Construction of C−N Bonds: A Facile Method for Synthesis of 2,4,6‐Trisubstituted Pyridines

Author(s) -

Gopalaiah Kovuru,

Rao Devarapalli Chenna,

Mahiya Kuldeep,

Tiwari Ankit

Publication year - 2018

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201800312

Subject(s) - chemistry , catalysis , oxidative cleavage , tandem , pyridine , oxidative phosphorylation , combinatorial chemistry , molecular oxygen , bond cleavage , reaction conditions , organic chemistry , biochemistry , materials science , composite material

Abundant and inexpensive iron, readily catalyzed the oxidative tandem reactions of arylalkylketones and benzylamines using molecular oxygen as the green oxidant in one‐pot solvent‐free conditions. 2,4,6‐Triaryl pyridines containing a wide variety of functional groups are synthesized from easily available starting materials. The synthetic importance of this reaction protocol has been demonstrated by preparing topoisomerase I and II inhibitors, and other valuable pyridine derivatives. Key intermediates are isolated and a plausible mechanism has been proposed.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research