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Rhodium(II)‐Catalyzed C−H Bond Carboxylation of Heteroarenes with CO 2
Author(s) -
Huang Raolin,
Li Shangda,
Fu Lei,
Li Gang
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800287
Subject(s) - chemistry , carboxylation , rhodium , catalysis , ligand (biochemistry) , redox , coumarin , carbon fixation , medicinal chemistry , phenols , combinatorial chemistry , organic chemistry , carbon dioxide , receptor , biochemistry
Abstract A method of Rh II ‐catalyzed C−H carboxylation of 2‐(imidazo[1,2‐ a ]pyridin‐2‐yl)phenols via CO 2 fixation under redox‐neutral conditions was reported, providing an access to a range of coumarin derivatives. A suitable diphosphine ligand was crucial for this reaction. This reaction could be performed under relatively lower temperature or in a shorter time than the alternative base‐promoted protocol.