I 2 /TBPB Mediated Oxidative Reaction to Construct of Imidazo[1,5‐α]pyridines under Metal‐Free Conditions | Zendy

Qin Mingda | Zendy; Tian Yuan | Zendy; Guo Xin | Zendy; Yuan Xinglong | Zendy; Yang Xueying | Zendy; Chen Baohua | Zendy

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I 2 /TBPB Mediated Oxidative Reaction to Construct of Imidazo[1,5‐α]pyridines under Metal‐Free Conditions

Author(s) -

Qin Mingda,

Tian Yuan,

Guo Xin,

Yuan Xinglong,

Yang Xueying,

Chen Baohua

Publication year - 2018

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201800285

Subject(s) - chemistry , catalysis , pyridine , cycloaddition , metal , oxidative phosphorylation , reaction conditions , combinatorial chemistry , organic chemistry , biochemistry

A new method for the synthesis of imidazo[1,5‐α]pyridines, one of the most important N‐heterocyclic compounds due to their wide application, was reported in this study. Specifically, using I 2 as a non‐metal catalyst and TBPB as an oxidant can efficiently facilitate the synthesis and avoid the use of a metal catalyst. The reaction between ethyl ( E )‐2‐(benzylideneamino)acetate and pyridine represents an unprecedented 1,3‐diolar cycloaddition in highly straightforward process with great value.

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