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I 2 /TBPB Mediated Oxidative Reaction to Construct of Imidazo[1,5‐α]pyridines under Metal‐Free Conditions
Author(s) -
Qin Mingda,
Tian Yuan,
Guo Xin,
Yuan Xinglong,
Yang Xueying,
Chen Baohua
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800285
Subject(s) - chemistry , catalysis , pyridine , cycloaddition , metal , oxidative phosphorylation , reaction conditions , combinatorial chemistry , organic chemistry , biochemistry
A new method for the synthesis of imidazo[1,5‐α]pyridines, one of the most important N‐heterocyclic compounds due to their wide application, was reported in this study. Specifically, using I 2 as a non‐metal catalyst and TBPB as an oxidant can efficiently facilitate the synthesis and avoid the use of a metal catalyst. The reaction between ethyl ( E )‐2‐(benzylideneamino)acetate and pyridine represents an unprecedented 1,3‐diolar cycloaddition in highly straightforward process with great value.