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Metal‐ and Base‐Free Direct N‐Arylation of Pyridazinones by Using Diaryliodonium Salts: An Anion Effect
Author(s) -
Xu Bowen,
Han Jianwei,
Wang Limin
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800268
Subject(s) - chemistry , yield (engineering) , base (topology) , metal ions in aqueous solution , metal , catalysis , combinatorial chemistry , base metal , free base , organic chemistry , polymer chemistry , mathematical analysis , materials science , mathematics , welding , metallurgy , salt (chemistry)
An efficient N‐arylation of pyridazinones with diaryliodonium salts has been developed without using base or metal catalysts. The reaction tolerated a variety of both diaryliodonium salts and pyridazinone derivatives with diverse functional groups. Furthermore, a drug candidate for treatment of neuropathic pain was synthesized with this procedure in good yield.